Mirogabalin is a gamma-amino acid derivative with selective and potent affinity for α2δ subunits of voltage-gated calcium channels (VGCCs).
This reduces Ca²⁺ influx in dorsal root ganglion neurons and suppresses presynaptic neurotransmitter release.
The result is decreased neuronal hyperexcitability and pain signal modulation in neuropathic conditions.
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Proper Packaging
Nervion (Mirogabalin) is indicated for the management of:
Adults: Initial dose 5 mg orally twice daily.
Increase by 5 mg weekly as needed, up to 15 mg twice daily.
Maintenance dose: 10–15 mg twice daily, individualized based on age, renal function, and symptom severity.
* Take medicine as directed by a registered physician.
Common: Somnolence, dizziness, edema, weight gain
Rare but serious:
Loss of consciousness, confusion, excessive drowsiness
Liver dysfunction (jaundice, nausea, vomiting, malaise)
Visual disturbances (blurred/double vision)
Seek medical attention if severe or persistent adverse effects occur.
No CYP450 induction or inhibition reported.
Plasma levels may rise when co-administered with Cimetidine or Probenecid.
Potentiation of CNS depressant effects may occur with alcohol or Lorazepam.
Hypersensitivity to Mirogabalin or any excipients
Patients with mild to moderate hepatic or renal impairment
Store at below 30°C and dry place, away from light and moisture. Keep out of the reach of children.
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